Evaluation of advanced protein oxidation and RAGE gene variants in the risk of laryngeal cancer

Laryngeal tumours with multifactorial etiopathogenesis constitute ∼1% of all body cancers. The imbalance between oxidative and antioxidative systems affects redox-homeostasis. stress generated by the continuous formation reactive oxygen species results in oxidation cellular molecules. present study investigated protein levels distribution receptors for advanced glycation end products (RAGE) variants risk laryngeal carcinoma (LC). RAGE gene polymorphisms were determined restriction endonuclease-based assay 120 controls LC patients. Spectrophotometric methods used to determine oxidant antioxidant parameters including protein-carbonyl-groups (PCO), advanced-oxidation-protein-products (AOPP), lipid-hydroperoxides (LPH), thiol-fractures, superoxide-dismutase (SOD) activity. distributions rs1800624 rs2070600 genotypes differed non-significantly among groups, however, rs2070600-Ser allele had a higher frequency While rs1800624-A carriers perineural lymphatic invasion, was advanced-stage patients muscle invasion. PCO, AOPP, LPH levels, SOD activity significantly According AUCs them are diagnostic importance, therefore, cut-off values determined. analysis combined effects showed that LPH, thiols, differ variants. Our suggest high serum may have on individually both affect progression disease interacting oxidant–antioxidant system.